New anti-trypanosomal active prenylated compounds from African propolis

The secondary metabolite composition of propolis has always been corroborated on the vegetation surrounding the bee hive. The plants chosen by the bees seem to exhibit activity to protect the hive from the surrounding environmental pressures which include protozoal attack. Two new stilbene compounds were isolated from Ghanian propolis which were formed either via geranylation or prenylation. These compounds exhibited moderate activity against Trypanosoma brucei brucei. While a new phlorogucinonone analogue was isolated from a Cameroon propolis that was found to possess high potency comparable to that of suramin.

https://www.sciencedirect.com/science/article/abs/pii/S1874390014001207